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There are three options to travel from Mumbai to Mysore : by train, bus and flight.
Of course, people do drive all the way to Myosre by car, making it the third option.
The most convenient and economical means to reach Mysore from Mumbai is by train. There are a couple of direct trains (weekly/bi-weekly) that connect Mumbai with Mysore. If that is not a possibility, look for one of the many trains that connect Bangalore with Mumbai. From Bangalore to Mysore is well connected by road and rail.
Route of Sharavati Express ( Train No:1036 / 1035 )

Route of Sharavati Express ( Train No:1036 / 1035 ). All the stops are not shown in the map.

There are two pairs of trains between Mumbai and Mysore. Sharavathi Express (Train No:1035) operates on Tuesdays from Dadar (DR) station on Tuesdays to Mysore Junction (MYS). It takes about 24 hours by Sharavathi Express to reach Mysore. This train leaves Dadar by 9.30 in the night and reaches Mysore railway station around the same time next day.
The second direct option is the long distance Ajmer Mysore Express (Train No:6209) that connects Ajmer in Rajastan with Mysore. You need to get to Kalyan Jn (KYN) to catch this train. This is a bi weekly train and you can catch it from Kalyan Jn for Mysore on every Fridays and Sundays. The train leaves Kalyan Jn by 1.10 past midnight and reaches Mysore after 7 in the morning, making it a 30 hour journey between Kalyan and Mysore.
About the return routes, Sharavati Express ( Train No:1036) leaves Mysore Junction every Thursdays by 6.15 in the morning. On the other hand the Rajastan bound Ajmer Express (Train No:6210) leaves Mysore on every Tuesdays and Thursdays 6.15 in the evening.
Route of Mysore-Ajmer Express

Route of Mysore-Ajmer Express Train No:6209/6210. Note all the stops are not shown in the route map

Both  Ajmer Express and Sharavati Express follow more or less the same route between Mumbai and Mysore up to Arsikere Junction (ASK). From there Sharavati Express takes a southward direct route to Mysore via Hassan. On the other hand Ajmer Express travel via Bangalore which is a bit longer route. Otherwise the route between Mumbai and Mysore is via Pune, Belgaum and Hubli.
There are at least three daily express trains and many weekly/bi-weekly trains connecting Bangalore with Mumbai. For example Udyan Express ( Train No:6529), Coimbatore Express (Train No:1013), Chalukya Express ( Train No:1017) and so on. Find out the railway stations for Mumbai and Bangalore for each trains. On the Bangalore side if possible, prefer the trains that take you to Bangalore City (SBC). It is much easy to get a connection train for Mysore from Bangalore City railway station, or if you have to travel to Mysore by bus, the KSRTC bus stand is just across the railway station. Bangalore to Mysore by bus or train is about 3 hours journey.
KSRTC operates a direct bus (A/c Volvo ) from Mumbai to Mysore. The bus leaves Mumbai ( Borivilly , Opp. Hotel Gokul) by 3.0 pm and travels to Mysore via Shimoga. You can book KSRTC tickets online at their website (www.ksrtc.in). And of course there are numerous private  bus services between Bangalore and Mumbai. Both Mangalore and Mysore too are well connected by bus services.
About the air connectivity, Mysore is connected to the rest of major airports in the country essentially via Bangalore. The regular flight operations to Mysore has been suspended .
A word of caution. Use the details provided here for your basic reference. Before taking travel decisions please consult more authentic and up to date official sources. Please do this especially for the schedules, as there could be changes, which might not be updated here.

There are two options to travel from Mumbai to Mysore : by train, bus and flight. Of course, people do drive all the way to Myosre by car, making it the third option.
The most convenient and economical means to reach Mysore from Mumbai is by train. There are a couple of direct trains (weekly/bi-weekly) that connect Mumbai with Mysore. If that is not a possibility, look for one of the many trains that connect Bangalore with Mumbai. From Bangalore to Mysore is well connected by road and rail.
There are two pairs of trains between Mumbai and Mysore. Sharavathi Express (Train No:1035) operates on Tuesdays from Dadar (DR) station on Tuesdays to Mysore Junction (MYS). It takes about 24 hours by Sharavathi Express to reach Mysore. This train leaves Dadar by 9.30 in the night and reaches Mysore railway station around the same time next day.
The second direct option is the long distance Ajmer Mysore Express (Train No:6209) that connects Ajmer in Rajastan with Mysore. You need to get to Kalyan Jn (KYN) to catch this train. This is a bi weekly train and you can catch it from Kalyan Jn for Mysore on every Fridays and Sundays. The train leaves Kalyan Jn by 1.10 past midnight and reaches Mysore after 7 in the morning, making it a 30 hour journey between Kalyan and Mysore.
About the return routes, Sharavati Express ( Train No:1036) leaves Mysore Junction every Thursdays by 6.15 in the morning. On the other hand the Rajastan bound Ajmer Express (Train No:6210) leaves Mysore on every Tuesdays and Thursdays 6.15 in the evening.
Both  Ajmer Express and Sharavati Express follow more or less the same route between Mumbai and Mysore up to Arsikere Junction (ASK). From there Sharavati Express takes a southward direct route to Mysore via Hassan. On the other hand Ajmer Express travel via Bangalore which is a bit longer route. Otherwise the route between Mumbai and Mysore is via Pune, Belgaum and Hubli.
There are at least three daily express trains and many weekly/bi-weekly trains connecting Bangalore with Mumbai. For example Udyan Express ( Train No:6529), Coimbatore Express (Train No:1013), Chalukya Express ( Train No:1017) and so on. Find out the railway stations for Mumbai and Bangalore for each trains. On the Bangalore side if possible, prefer the trains that take you to Bangalore City (SBC). It is much easy to get a connection train for Mysore from Bangalore City railway station, or if you have to travel to Mysore by bus, the KSRTC bus stand is just across the railway station. Bangalore to Mysore by bus or train is about 3 hours journey.
KSRTC operates a direct bus (A/c Volvo ) from Mumbai to Mysore. The bus leaves Mumbai ( Borivilly , Opp. Hotel Gokul) by 3.0 pm and travels to Mysore via Shimoga. You can book KSRTC tickets online at their website (www.ksrtc.in). And of course there are numerous private  bus services between Bangalore and Mumbai. Both Mangalore and Mysore too are well connected by bus services.

About the air connectivity, Mysore is connected to the rest of major airports in the country essentially via Bangalore and Chennai. There is a single daily flight (Kingfisher Red) between Channai (MAA) and Mysore (MYQ) via Bangalore (BLR) . To that extend you can opt for a flight connection from Mumbai to Mysore via Bangalore. See also :  Mysore Airport.
A word of caution. Use the details provided here for your basic reference. Before taking travel decisions please consult more authentic and up to date official sources. Please do this especially for the schedules, as there could be changes, which might not be updated here.

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